Manchester City will host Liverpool in the FA Cup quarter-finals, while Premier League leaders Arsenal travel to second-tier Southampton following Monday’s draw.

Pep Guardiola’s City secured their spot in the last eight with a 3-1 win at Newcastle United on Saturday. Liverpool also progressed with a 3-1 victory at Wolverhampton Wanderers. City have reached the quarter-finals for the eighth consecutive season and are aiming for a fourth straight FA Cup final appearance as they chase a possible quadruple.

Arsenal, record 14-time FA Cup winners, visit Southampton. Mikel Arteta’s side are also pursuing a quadruple, having reached the League Cup final and the Champions League last 16.

Third-tier Port Vale caused a major upset in the fifth round on Sunday, beating Premier League side Sunderland 1-0. They face a tough test against Chelsea, who advanced after a 4-2 extra-time win at Wrexham on Saturday.

Leeds United travel to West Ham United, who defeated Brentford 5-3 on penalties on Monday following a 2-2 draw after extra time. West Ham’s Konstantinos Mavropanos scored the decisive spot kick.

FA Cup Quarter-Final Fixtures:

Southampton vs Arsenal

Chelsea vs Port Vale

Manchester City vs Liverpool

West Ham United vs Leeds United

All matches are scheduled for the weekend of April 4-5.

-Reporting by Tommy Lund in Gdansk; Editing by Ken Ferris/Reuters